Document Type

Article

Publication Date

7-1-2010

Keywords

Dual modes of signal transduction, Fluorescent chemosensors, Organophosphorus compounds, Pollutants

Abstract

Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve agents and chemical warfare agents, such as, VX, Soman and Sarin. Unfortunately, widespread and frequent commercial use of OP-based compounds in agricultural lands has resulted in their presence as residues in crops, livestock, and poultry products and also led to their migration into aquifers. Thus, the design of new sensors with improved analyte selectivity and sensitivity is of paramount importance in this area. Herein, we review recent advances in the development of fluorescent chemosensors for toxic OP pesticides and related compounds. We also discuss challenges and progress towards the design of future chemosensors with dual modes for signal transduction. © 2010 by the authors; licensee MPDI, Basel, Switzerland.

Journal Title

Sensors

Volume

10

Issue

7

First Page

7018

Last Page

7043

DOI

https://doi.org/10.3390/s100707018

First Department

Chemistry and Biochemistry

Acknowledgements

Open access article retrieved March 12, 2021 from https://www.mdpi.com/1424-8220/10/7/7018

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