Date of Award
12-17-2025
Document Type
Honors Thesis
Department
Chemistry & Biochemistry
First Advisor
Melissa Poua
Abstract
Phthalimides are a group of compounds among bicyclic non-aromatic nitrogen heterocycles that have gained recognition for their bioactivity across various fields, notably anti-cancer, anti-microbial, anti-oxidant, and anti-inflammatory. This study discusses the synthesis of a novel phthalimide derivative and provides an analysis of its biological activity. It was conducted through a Boric acid Imide synthesis and yielded a successful derivative using hexylamine. The product was evaluated in vitro for antimicrobial, anticoagulant, and anti-inflammatory properties using Kirby-Bauer disk diffusion, clotting time, hemolysis inhibition, and protein denaturation assays. It showed mild anticoagulant and anti-inflammatory activity.
Recommended Citation
Mangundah, Beaula, "Design, Synthesis and Biological Activities of N-substituted Phthalimide Derivative" (2025). Honors Theses. 315.
https://digitalcommons.andrews.edu/honors/315
Subject Area
Heterocyclic compounds; Phthalimides
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.