Date of Award

12-11-2025

Document Type

Honors Thesis

Department

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First Advisor

Melissa Poua

Abstract

The rise of antimicrobial-resistant bacteria in the healthcare industry has led to devastating effects in recent years, ranging from increased risks associated with hospital treatment to longer illness duration, which may eventually lead to increased death rates (Naghavi, Mohsen et al, 2024). To combat this ongoing challenge, this project aims to synthesize amidoximes, which are organic derivatives of carboxylic acids with an oxime and an amino acid group. Amidoximes have been utilized in various clinical applications, including antituberculosis medication, hypotensives, antiarrhythmics, antibacterials, and antifungals (J. Chil et al., 2011). -- The focus of this project was to test their antibacterial properties and their susceptibility to bioisosterism, which is a useful feature in producing effective drugs. In exploring the antibacterial effects of amidoximes, this could lead to further discoveries on their potential usage in pharmaceuticals and their efficacy in treating selected strains of bacteria that have been known to be prevalent in healthcare settings- Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. From the research, it was discovered that the amidoxime derived from the nitrile 3.4 dihydroxybenzonitrile was the most effective against Pseudomonas aeruginosa and Staphylococcus aureus, while none of the amidoximes synthesized were effective against Escherichia coli. This proved to be a significant result as Pseudomonas aeruginosa and Staphylococcus aureus are known to form biofilms which are difficult to treat, they have also been included in poor outcomes seen by cystic fibrosis patients as they affect lung function among other diseases . (Orazi et.al 2019)

Subject Area

Amidoximes; Pseudomonas aeruginosa; Staphylococcus aureus; Escherichia coli

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