Date of Award
2015
Document Type
Honors Thesis
Department
Chemistry & Biochemistry
First Advisor
Ryan T. Hayes
Abstract
Heterocyclic Amines (HCAs) are a group of mutagenic and caricinogenic chemicals found in muscle meat after grilling, frying, or broiling. Research studies show that very low amounts of HCAs are created from creatin(in)e reacting with another amino acid at temperatures greater than 200 C. Other studies show that plant-based arginine can substitute for creatin(in)e forming a new class of mutagenic HCAs, but also in low yields. We attempted to develop a direct, higher yielding method of producing these arginine-HCAs based on a procedure previously used to synthesize creatine-HCAs. With greater amounts of arginine-HCAs, chemical characterization and toxicity assessment could be improved.
Recommended Citation
Stewart, Andrew, "The Synthesis of Arginine-based Heterocyclic Amines" (2015). Honors Theses. 105.
https://dx.doi.org/10.32597/honors/105/
https://digitalcommons.andrews.edu/honors/105
Subject Area
Heterocyclic compounds., Amines., Carcinogens.
Presentation Record URL
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/105/