Location

Buller Hallway

Start Date

3-6-2015 2:30 PM

End Date

3-6-2015 4:00 PM

Description

Heterocyclic Amines (HCAs) are a group of mutagenic and carcinogenic chemicals found in muscle meat after grilling, frying, or broiling. Research studies show that very low amounts of HCAs are created from creatinine reacting with another amino acid at temperatures greater than 200 °C. Other studies show that plant-based arginine can substitute for creatine forming a new class of mutagenic HCAs, but also in low yields. We sought to develop a direct, higher yielding method of producing these arginine-HCAs based on a procedure previously used to synthesize creatine-HCAs. Greater amounts of arginine-HCA speeds analysis, chemical characterization, and toxicity assessment.

Acknowledgments

J.N. Andrews Honors Scholar and Undergraduate Research Scholar

Advisor: Ryan Hayes, Chemistry & Biochemistry

Included in

Chemistry Commons

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Mar 6th, 2:30 PM Mar 6th, 4:00 PM

P-24 Synthesis of Arginine-Based Heterocyclic Amines

Buller Hallway

Heterocyclic Amines (HCAs) are a group of mutagenic and carcinogenic chemicals found in muscle meat after grilling, frying, or broiling. Research studies show that very low amounts of HCAs are created from creatinine reacting with another amino acid at temperatures greater than 200 °C. Other studies show that plant-based arginine can substitute for creatine forming a new class of mutagenic HCAs, but also in low yields. We sought to develop a direct, higher yielding method of producing these arginine-HCAs based on a procedure previously used to synthesize creatine-HCAs. Greater amounts of arginine-HCA speeds analysis, chemical characterization, and toxicity assessment.