Date of Award
Master of Science
College of Arts and Sciences
John F. Stout
In partially purified cell-free extracts of rat liver, nonexhaustive, daily exercise results in a 40 to 90% inhibition of FAB by decreasing the catalytic activity of acetyl coenzyme A carboxylase (ACC), the rate-limiting enzyme in the de novo FAB pathway in vitro. ACC inhibitory mechanisms are postulated to include: phosphorylation of ACC and production of a noncompetitive inhibitory substance.
Data obtained after purification of rat liver ACC to homogeneity suggest that decreased ACC activity in exercised rats cannot be attributed to the well-documented control of ACC by reversible phosphorylation, but are more likely due to the presence of a noncompetitive inhibitory substance located in the partially purified cell-free extract of rat liver.
Fatty acids, Rats--Exercise
Francis, Rita Priyadarshani, "Regulation of Fatty Acid Biosynthesis by Physical Exercise Mechanisms of Inhibition" (1990). Master's Theses. 94.
Files over 3MB may be slow to open. For best results, right-click and select "save as..."