Date of Award
3-30-2026
Document Type
Thesis
Department
Biology
First Advisor
Peter J. Lyons
Abstract
Basophils are leukocytes that mediate inflammatory responses through the exocytosis of granules containing enzymes and inflammatory mediators. Carboxypeptidase O (CPO) is a protease with Cterminal acidic amino acid specificity and is expressed in basophils. CPO expression and localization were assessed in KU812 basophil cells via Western blotting and immunocytochemistry. CPO expression decreased upon degranulation and is localized to cytosolic puncta. These data suggest that CPO may be localized in basophil granules and released upon degranulation.
Recommended Citation
Balorda, Etien, "Carboxypeptidase O Expression in KU812 Basophil Cells Decreases upon Degranulation" (2026). Honors Theses. 319.
https://digitalcommons.andrews.edu/honors/319
Subject Area
Carboxypeptidases; Leucocytes; Basophils; Granulation
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.