Date of Award
12-16-2025
Document Type
Honors Thesis
First Advisor
Melissa PouaAn
Abstract
Antimicrobial resistance is a global health challenge, rendering once-effective antibiotics less potent or entirely ineffective. In response, there is increasing interest in developing antimicrobial agents through environmentally sustainable methods. In this study, a fluorinated aurone derivative, (2Z)-2-[(4-fluorophenyl)methylidene]-1-benzofuran-3-one, was synthesized using a green Knoevenagel condensation approach. Eco-friendly catalysts were employed to minimize environmental impact and avoid hazardous byproducts. Product formation was confirmed to avoid wasting resources. The compound was evaluated for antimicrobial properties using a Kirby-Bauer plate, but did not demonstrate consistent or significant antimicrobial activity, therefore lacking promise as a standalone antibiotic.
Recommended Citation
Olofernes, Rod Albert C., "Green Synthesis of and Antimicrobial Susceptibility Testing of (2Z)-2-[(4-fluorophenyl)methylidene]-1-benzofuran-3-one" (2025). Honors Theses. 313.
https://digitalcommons.andrews.edu/honors/313
Subject Area
Anti-infective agents; Antibiotics
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
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