Date of Award
4-19-2024
Document Type
Honors Thesis
Department
Biology
First Advisor
Brian Y. Y. Wong
Abstract
Chinese medicinal herbs have been found to contain bioactive phytochemicals with anti-cancer properties. Herbal extracts induce apoptosis in cancer cells by modulating levels of pro- and anti-apoptotic proteins. A previous study showed that a commonly used herb, Scutellaria barbata, significantly induced apoptosis in the breast cancer cell line MDA-MB-157 and the therapy-resistant breast cancer cell line 93B. However, the effects of two different Chinese herbs, Oldenlandia diffusa (OD) and Bryophyllum pinnatum (BP) on these breast cancer cells are not known. This project indicates the influence of the herbs OD and BP on apoptosis of breast cancer cell line MDA-MB-157 in comparison to 93B through modulating the levels of pro- and anti-apoptotic proteins.
Recommended Citation
Wolf, Sarah, "Induction and Modulation of Apoptosis in Breast Cancer Cells MDA-MB-157 and 93B by Chinese Medicinal Herbs Oldenlandia diffusa and Bryophyllum pinnatum" (2024). Honors Theses. 292.
https://digitalcommons.andrews.edu/honors/292
Subject Area
Breast--Cancer; Apoptosis; Herbs--China--Therapeutic use; Oldenlandia; Kalanchoe
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.