Date of Award
4-19-2024
Document Type
Honors Thesis
Department
Biology
First Advisor
Denise L. Smith
Second Advisor
Desmond H. Murray
Abstract
Glioblastoma is treated with Temozolomide (TMZ), a lipophilic alkylating drug that can cross the brain-blood barrier. To confront drug resistance, this research aimed to synthesize novel TMZ amide hybrids by using the acid chloride method, replacing an amino group with a primary amine. These novel hybrids were tested on U87-MG cells to determine if the primary amines with greater anticancer properties and lipophilicity have enhanced the drug's anticancer activity and bioavailability. The calculated lethal concentration 50 (LC50) of the hybrids ranged from 0.005 mg/mL to 0.2258 mg/mL, with some demonstrating greater anticancer effects than TMZ itself.
Recommended Citation
Kim, Sion, "Synthesis of Novel Temozolomide Amides as Potential Anti-Glioblastoma Agents" (2024). Honors Theses. 284.
https://digitalcommons.andrews.edu/honors/284
Subject Area
Gliomas; Alkylating agents; Amines
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
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