Date of Award
4-1-2022
Document Type
Honors Thesis
Department
Biology
First Advisor
Denise Smith
Abstract
This research tested the effectiveness of novel compound 3,4-dimethoxybenzaldehyde, demonstrated to have anti-cancer properties. U87MG Glioblastoma cells were exposed to the compound at its LC50 concentration, then processed to collect proteins from the cells. Proteins were analyzed via Western blotting for specific protein levels of matrix metalloproteinase 2 and 9 (MMP) and disintegrin and metalloprotease 12 and 17 (ADAM). Previous research indicates these proteins are involved in the invasive properties of glioblastoma cells. Westerns were quantified with ImageJ and compared using a one-way ANOVA. Results indicate the compound has minimal effect upon the expression of MMP2, MMP9, ADAM12, ADAM17 proteins.
Recommended Citation
Muranyi, Andras, "Analysis of Invasion Proteins MMP2, MMP9, ADAM12, and ADAM17 in Glioblastoma U87MG Cells treated with anti-cancer compound 3,4-dimethoxybenzaldehyde" (2022). Honors Theses. 265.
https://digitalcommons.andrews.edu/honors/265
Subject Area
Gliomas; Glioblastoma multiforme; Cancer--Treatment; Cancer--Chemotherapy; 3, 4-dimethoxybenzaldehyde
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.