Date of Award


Document Type

Honors Thesis


Chemistry & Biochemistry

First Advisor

Melissa Poua

Second Advisor

Desmond Hartwell Murray


NDM-1 K. pneumoniae is a highly resistant bacterial organism that is capable of causing debilitating nosocomial infections in immunocompromised patients. Only "last-resort" antibiotics--such as colistin--work against this organism. Therefore, new antibiotics are needed to help fight against these types of infections. APT-6K is a novel compound that was demonstrated to be effective against MRSA with nanomolar concentrations in a prior study. Novel methods of APT-6K synthesis and its testing for antibiotic effects against NDM-1 K. pneumoniae were attempted in this research. APT-6K synthesis was unsuccessful. Commercially-prepared APT-6K also did not demonstrate growth inhibition against NDM-1 K. pneumoniae nor against a wild-type K. pneumoniae. Suggestions for future research are discussed.

Subject Area

Klebsiella pneumoniae; Nosocomial infections; Antibiotics; Drug resistance in microorganisms; APT-6K