Date of Award
3-31-2022
Document Type
Honors Thesis
Department
Chemistry & Biochemistry
First Advisor
Melissa Poua
Second Advisor
Desmond Hartwell Murray
Abstract
NDM-1 K. pneumoniae is a highly resistant bacterial organism that is capable of causing debilitating nosocomial infections in immunocompromised patients. Only "last-resort" antibiotics--such as colistin--work against this organism. Therefore, new antibiotics are needed to help fight against these types of infections. APT-6K is a novel compound that was demonstrated to be effective against MRSA with nanomolar concentrations in a prior study. Novel methods of APT-6K synthesis and its testing for antibiotic effects against NDM-1 K. pneumoniae were attempted in this research. APT-6K synthesis was unsuccessful. Commercially-prepared APT-6K also did not demonstrate growth inhibition against NDM-1 K. pneumoniae nor against a wild-type K. pneumoniae. Suggestions for future research are discussed.
Recommended Citation
Bofetiado, Alec, "Attempted Synthesis & Antibacterial Properties of APT-6K Against NDM-1 K. Pneumoniae" (2022). Honors Theses. 260.
https://digitalcommons.andrews.edu/honors/260
Subject Area
Klebsiella pneumoniae; Nosocomial infections; Antibiotics; Drug resistance in microorganisms; APT-6K
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.