Date of Award
4-30-2020
Document Type
Honors Thesis
Department
Chemistry & Biochemistry
First Advisor
Lisa Ahlberg
Abstract
Design of a novel isoxazoline class drug for the suppressive treatment of erythrocytic malaria through the inhibition of Plasmodium Falciparum Gylceraldehyde-3-phosphate Dehydrogenase (PfGAPDH) gave rise to creation of a synthetic plan for the proposed target molecule α-amino- 3-bromo-4,5-dihydroisoxazol-5-yl propionic acid. A literature-based analysis of the moieties targeting the PfGADPH active site led to the design of the target molecule. Subsequently, an exploration of the literature yielded a possible bifold synthetic plan. Attempts at a model epoxidation reaction using mCPBA and further efforts towards the synthesis of a 3- bromoisoxazoline were shown to be successful using GCMS analysis.
Recommended Citation
Ware, Peyton, "Design of a Novel Isoxazoline Class Drug for the Suppressive Treatment of Malaria" (2020). Honors Theses. 239.
https://dx.doi.org/10.32597/honors/239/
https://digitalcommons.andrews.edu/honors/239
Subject Area
Malaria--Treatment; Heterocyclic compounds; Isoxazolines.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/239/
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