Date of Award

4-30-2020

Document Type

Honors Thesis

Department

Biology

First Advisor

Denise Smith

Abstract

The primary objectives of this interdisciplinary study were the synthesis of novel heterocyclic arylidenes and the investigation of their anticancer activity against U87 glioblastoma cell viability. Recently, novel hybrid derivatives have been considered as potential candidates for treating glioblastoma, demonstrating a synergistic anticancer effect in previous studies. 12 heterocyclic arylidenes with various functional groups, including halogens and boronic acid, were produced via a Knoevenagel condensation. These compounds and their starting reagents were then administered to U87 glioblastoma cancer cells at graded concentrations within a 12-well cell viability assay to determine each compound’s lethal concentration 50 (LC50). The LC50 of each compound was then compared to determine the effects of substituent type and position on anticancer activity. Although these arylidenes displayed some anticancer effects, their high LC50 suggest they have no significant effect on U87 glioblastoma cell viability and proliferation.

Subject Area

Glioblastoma multiforme; Antineoplastic agents; Brain--Cancer; Arylidene

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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