Date of Award
4-30-2020
Document Type
Honors Thesis
Department
Biology
First Advisor
Marlene Murray
Abstract
Bipolar disorder is a mental disorder associated with abnormal inositol levels. Preliminary studies show omega-3 fatty acids alter intracellular inositol levels; however, the cellular mechanism behind this process is unknown. Therefore, the focus of this study is to determine the effects of the omega-3 fatty acid docosahexaenoic acid (DHA) on the expression of INM1 which encodes inositol monophosphatase. Using yeast as our model system, cells were grown in varying concentrations DHA and the expression on INM1 was determined by RT-qPCR. The results show INM1 expression increased with increasing concentrations of DHA; thus, the effects of DHA on inositol levels may be exerted via its impact on INM1 expression.
Recommended Citation
Kang, Haley, "The Effects of the Omega-3 Fatty Acids Docosahexaenoic Acid on INM1 Gene Expression in Saccharomyces Cerevisiae" (2020). Honors Theses. 221.
https://dx.doi.org/10.32597/honors/221/
https://digitalcommons.andrews.edu/honors/221
Subject Area
Omega-3 fatty acids; Docosahexaenoic acid; Gene expression; Saccharomyces cerevisiae
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/221/