Date of Award
4-6-2019
Document Type
Honors Thesis
Department
Chemistry & Biochemistry
First Advisor
Lisa Ahlberg
Abstract
Progression of Alzheimer's disease is associated with a loss of Ml receptor activation in the brain. However, a lack of clinical success following attempts to activate the Ml receptor at the orthosteric site has contributed to a transition towards the allosteric pocket of the receptor. Here, positive allosteric modulators (PAMs) interact to potentiate the acetylcholine response. Recent research proposes that optimization of PAM activity at the expense of intrinsic agonism may posit a means to limit adverse side effects. Therefore, this project proposes a design and synthesis of a novel isoxazoline as a potent PAM agent with weak intrinsic agonism.
Recommended Citation
Roosenberg, Josselyn, "Design and Synthesis of a Novel lsoxazoline as a Potential PAM-Agonist" (2019). Honors Theses. 215.
https://dx.doi.org/10.32597/honors/215
https://digitalcommons.andrews.edu/honors/215
Subject Area
Allosteric regulation; Alzeheimer's disease, Isoxazoline
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/215
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