Date of Award
Chemistry & Biochemistry
Stilbenes are naturally occurring compounds that have exhibited antibacterial activity, although the biological effect of various stilbenes differs for Gram-positive and Gram-negative strains of bacteria. In prior research, cyanostilbenes have shown slight antibacterial activity (Brownlee, et al. 1943). This project aims to explore whether hybrid oxygenated a-cyanostilbenes possessing a boronic acid pharmacophore exhibits significant antibacterial activity (Das et al. 2013). The biological activity against Staphylocococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was tested using the Kirby-Bauer text. No inhibition of E. coli growth was shown while S. aureus was partially inhibited.
Kim, Yewon, "Synthesis of Oxygenated Boronic Acid Substituted a-Cyanostilbenes For Use as Antibacterial" (2018). Honors Theses. 183.
Stilbene; Antibacterial agents; Boronic acid stilbenes
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