Date of Award
4-6-2018
Document Type
Honors Thesis
Department
Chemistry and Biochemistry
First Advisor
Desmond Murray
Abstract
Stilbenes are naturally occurring compounds that have exhibited antibacterial activity, although the biological effect of various stilbenes differs for Gram-positive and Gram-negative strains of bacteria. In prior research, cyanostilbenes have shown slight antibacterial activity (Brownlee, et al. 1943). This project aims to explore whether hybrid oxygenated a-cyanostilbenes possessing a boronic acid pharmacophore exhibits significant antibacterial activity (Das et al. 2013). The biological activity against Staphylocococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was tested using the Kirby-Bauer text. No inhibition of E. coli growth was shown while S. aureus was partially inhibited.
Recommended Citation
Kim, Yewon, "Synthesis of Oxygenated Boronic Acid Substituted a-Cyanostilbenes For Use as Antibacterial" (2018). Honors Theses. 183.
https://dx.doi.org/10.32597/honors/183/
https://digitalcommons.andrews.edu/honors/183
Subject Area
Stilbene; Antibacterial agents; Boronic acid stilbenes
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/183/
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