P-24 Attempted Synthesis & Antibacterial Pr operties of APT-6K Against NDM-1 K. pneumoniae
Department
Medical Laboratory Sciences
Abstract
NDM-1 K. pneumoniae is a highly resistant bacterial organism that is capable of causing debilitating nosocomial infections in immunocompromised patients. Only “last-resort” antibiotics—such as colistin—work against this organism. Therefore, new antibiotics are needed to help fight against these types of infections. APT-6K is a novel compound that was demonstrated to be effective against MRSA with nanomolar concentrations in a prior study. Novel methods of APT-6K synthesis and its testing for antibiotic effects against NDM-1 K. pneumoniae were attempted in this research. However, APT-6K synthesis was unsuccessful. Commercially-prepared APT-6K also did not demonstrate growth inhibition against NDM-1 K. pneumoniae nor against a wild-type K. pneumoniae. Suggestions for future research are discussed.
Location
Buller Hall 251
Start Date
3-11-2022 1:30 PM
End Date
3-11-2022 3:30 PM
P-24 Attempted Synthesis & Antibacterial Pr operties of APT-6K Against NDM-1 K. pneumoniae
Buller Hall 251
NDM-1 K. pneumoniae is a highly resistant bacterial organism that is capable of causing debilitating nosocomial infections in immunocompromised patients. Only “last-resort” antibiotics—such as colistin—work against this organism. Therefore, new antibiotics are needed to help fight against these types of infections. APT-6K is a novel compound that was demonstrated to be effective against MRSA with nanomolar concentrations in a prior study. Novel methods of APT-6K synthesis and its testing for antibiotic effects against NDM-1 K. pneumoniae were attempted in this research. However, APT-6K synthesis was unsuccessful. Commercially-prepared APT-6K also did not demonstrate growth inhibition against NDM-1 K. pneumoniae nor against a wild-type K. pneumoniae. Suggestions for future research are discussed.
Acknowledgments
Advisors: Melissa Poua, Medical Laboratory Sciences; Desmond Murray, Chemistry & Biochemistry