Event Title

P-22 Synthesis of an Anticancer Molecule Containing an Isoxazoline ring and a Dibenz[b,f]azepine

Location

Buller Hall 250

Start Date

3-11-2022 1:30 PM

End Date

3-11-2022 3:30 PM

Department

Chemistry and Biochemistry

Description

This poster displays an anticancer molecule synthesis and describes the biological mechanism targeted by this model compound. The synthesis of this model allows us to test the chemistry described in the literature and then apply it to a new proposed compound. Our proposed structure is hypothesized to be a more effective anticancer molecule than the model with which we start. Based on research of known agonist AC-5216 and antagonist PK11195 of the TSPO receptor in mitochondrial membranes, the addition of an isoxazoline ring to the model structure is hypothesized to induce apoptosis of cancer cells.

Acknowledgments

Advisor: Lisa Ahlberg, Chemistry & Biochemistry

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Mar 11th, 1:30 PM Mar 11th, 3:30 PM

P-22 Synthesis of an Anticancer Molecule Containing an Isoxazoline ring and a Dibenz[b,f]azepine

Buller Hall 250

This poster displays an anticancer molecule synthesis and describes the biological mechanism targeted by this model compound. The synthesis of this model allows us to test the chemistry described in the literature and then apply it to a new proposed compound. Our proposed structure is hypothesized to be a more effective anticancer molecule than the model with which we start. Based on research of known agonist AC-5216 and antagonist PK11195 of the TSPO receptor in mitochondrial membranes, the addition of an isoxazoline ring to the model structure is hypothesized to induce apoptosis of cancer cells.