Poster Title
P-22 Synthesis of an Anticancer Molecule Containing an Isoxazoline ring and a Dibenz[b,f]azepine
Department
Chemistry and Biochemistry
Abstract
This poster displays an anticancer molecule synthesis and describes the biological mechanism targeted by this model compound. The synthesis of this model allows us to test the chemistry described in the literature and then apply it to a new proposed compound. Our proposed structure is hypothesized to be a more effective anticancer molecule than the model with which we start. Based on research of known agonist AC-5216 and antagonist PK11195 of the TSPO receptor in mitochondrial membranes, the addition of an isoxazoline ring to the model structure is hypothesized to induce apoptosis of cancer cells.
Location
Buller Hall 250
Start Date
3-11-2022 1:30 PM
End Date
3-11-2022 3:30 PM
P-22 Synthesis of an Anticancer Molecule Containing an Isoxazoline ring and a Dibenz[b,f]azepine
Buller Hall 250
This poster displays an anticancer molecule synthesis and describes the biological mechanism targeted by this model compound. The synthesis of this model allows us to test the chemistry described in the literature and then apply it to a new proposed compound. Our proposed structure is hypothesized to be a more effective anticancer molecule than the model with which we start. Based on research of known agonist AC-5216 and antagonist PK11195 of the TSPO receptor in mitochondrial membranes, the addition of an isoxazoline ring to the model structure is hypothesized to induce apoptosis of cancer cells.
Acknowledgments
Advisor: Lisa Ahlberg, Chemistry & Biochemistry