Poster Title
P-20 Analysis of Invasion Proteins in Glioblastoma U87MG Cells Treated with Various Novel Hybrid Anti-cancer Compounds
Department
Biology
Abstract
This research tested effectiveness of compounds 2-TBH, PKP2, PKP3, PKP5, and DMOB, demonstrated to have anti-cancer properties. Glioblastoma cells were exposed to each compound at the LC50 concentration, then processed to collect proteins from the cells. Proteins were analyzed via Western blotting for specific protein levels of matrix metalloproteinase 2 and 9 (MMP) and disintegrin and metalloprotease 12 and 17 (ADAM). Previous research indicates these proteins are involved in the invasive properties of glioblastoma cells. Preliminary results show that the different compounds result in varying levels of MMP-2 and 9 as well as ADAM-12 and 17 proteins.
Location
Buller Hall 250
Start Date
3-11-2022 1:30 PM
End Date
3-11-2022 3:30 PM
P-20 Analysis of Invasion Proteins in Glioblastoma U87MG Cells Treated with Various Novel Hybrid Anti-cancer Compounds
Buller Hall 250
This research tested effectiveness of compounds 2-TBH, PKP2, PKP3, PKP5, and DMOB, demonstrated to have anti-cancer properties. Glioblastoma cells were exposed to each compound at the LC50 concentration, then processed to collect proteins from the cells. Proteins were analyzed via Western blotting for specific protein levels of matrix metalloproteinase 2 and 9 (MMP) and disintegrin and metalloprotease 12 and 17 (ADAM). Previous research indicates these proteins are involved in the invasive properties of glioblastoma cells. Preliminary results show that the different compounds result in varying levels of MMP-2 and 9 as well as ADAM-12 and 17 proteins.
Acknowledgments
Advisor: Denise Smith, Biology