Poster Title
P-12 The Effects of Docosahexaenoic Acid on INM1 Gene Expression
Abstract
Bipolar disorder is associated with abnormal inositol levels, and preliminary studies show omega-3 fatty acids alter intracellular inositol levels. However, the cellular mechanism behind this process is unknown. Therefore, the focus of this study is to determine the effects of the omega-3 fatty acid docosahexaenoic acid (DHA) on the expression of INM1 which encodes inositol monophosphatase. Using yeast as our model system, cells were grown in varying concentrations DHA and the expression on INM1 was determined by RT-qPCR. The results showed that INM1 expression increased with increasing concentrations of DHA, and effects of DHA on inositol levels may be exerted via its impact on INM1 expression.
Start Date
2-28-2020 2:30 PM
P-12 The Effects of Docosahexaenoic Acid on INM1 Gene Expression
Bipolar disorder is associated with abnormal inositol levels, and preliminary studies show omega-3 fatty acids alter intracellular inositol levels. However, the cellular mechanism behind this process is unknown. Therefore, the focus of this study is to determine the effects of the omega-3 fatty acid docosahexaenoic acid (DHA) on the expression of INM1 which encodes inositol monophosphatase. Using yeast as our model system, cells were grown in varying concentrations DHA and the expression on INM1 was determined by RT-qPCR. The results showed that INM1 expression increased with increasing concentrations of DHA, and effects of DHA on inositol levels may be exerted via its impact on INM1 expression.
Acknowledgments
J.N. Andrews Honors Scholar
Mentor: Marlene Murray, Biology