Event Title

P-02 Synthesis of 3-substituted Hybrid Coumarins and Testing of Their Anticancer Properties

Location

Buller Hall Lobby

Start Date

3-8-2019 2:30 PM

Description

Glioblastoma has the highest incidence among brain and central nervous system cancers and is known for its high malignancy and poor prognosis. Coumarin, a compound that can be synthesized and found in nature, has demonstrated anticancer activity and other properties that suggest it could be successful in the treatment of glioblastoma. In this project, the Knoevenagel reaction, consisting of a reflux reaction followed by isolation, was used to synthesize eight different hybrid products achieved by varying reaction reactants. These hybrid coumarin compounds were tested on glioblastoma cancer cells in order to observe and record glioblastoma cell death.

Acknowledgments

Supervising Professor: Dr. Denise Smith

Secondary Professor: Dr. Desmond Murray

Funding: Faculty Research Grant

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Mar 8th, 2:30 PM

P-02 Synthesis of 3-substituted Hybrid Coumarins and Testing of Their Anticancer Properties

Buller Hall Lobby

Glioblastoma has the highest incidence among brain and central nervous system cancers and is known for its high malignancy and poor prognosis. Coumarin, a compound that can be synthesized and found in nature, has demonstrated anticancer activity and other properties that suggest it could be successful in the treatment of glioblastoma. In this project, the Knoevenagel reaction, consisting of a reflux reaction followed by isolation, was used to synthesize eight different hybrid products achieved by varying reaction reactants. These hybrid coumarin compounds were tested on glioblastoma cancer cells in order to observe and record glioblastoma cell death.