Poster Title
P-02 Synthesis of 3-substituted Hybrid Coumarins and Testing of Their Anticancer Properties
Abstract
Glioblastoma has the highest incidence among brain and central nervous system cancers and is known for its high malignancy and poor prognosis. Coumarin, a compound that can be synthesized and found in nature, has demonstrated anticancer activity and other properties that suggest it could be successful in the treatment of glioblastoma. In this project, the Knoevenagel reaction, consisting of a reflux reaction followed by isolation, was used to synthesize eight different hybrid products achieved by varying reaction reactants. These hybrid coumarin compounds were tested on glioblastoma cancer cells in order to observe and record glioblastoma cell death.
Location
Buller Hall Lobby
Start Date
3-8-2019 2:30 PM
P-02 Synthesis of 3-substituted Hybrid Coumarins and Testing of Their Anticancer Properties
Buller Hall Lobby
Glioblastoma has the highest incidence among brain and central nervous system cancers and is known for its high malignancy and poor prognosis. Coumarin, a compound that can be synthesized and found in nature, has demonstrated anticancer activity and other properties that suggest it could be successful in the treatment of glioblastoma. In this project, the Knoevenagel reaction, consisting of a reflux reaction followed by isolation, was used to synthesize eight different hybrid products achieved by varying reaction reactants. These hybrid coumarin compounds were tested on glioblastoma cancer cells in order to observe and record glioblastoma cell death.
Acknowledgments
Supervising Professor: Dr. Denise Smith
Secondary Professor: Dr. Desmond Murray
Funding: Faculty Research Grant