P-13 Methodology for the Synthesis of an Antibacterial Isoxazoline Ring
Abstract
Due to the growing need of antibiotics in modern day medicine, this study attempts to find a method that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecule to create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the active site zinc ion.
Location
Buller Hall Lobby
Start Date
3-8-2019 2:30 PM
P-13 Methodology for the Synthesis of an Antibacterial Isoxazoline Ring
Buller Hall Lobby
Due to the growing need of antibiotics in modern day medicine, this study attempts to find a method that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecule to create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the active site zinc ion.
Acknowledgments
Supervising Professor: Dr. Lisa Ahlberg