P-13 Methodology for the Synthesis of an Antibacterial Isoxazoline Ring

Buller Hall Lobby

Due to the growing need of antibiotics in modern day medicine, this study attempts to find a method that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecule to create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the active site zinc ion.