Event Title

P-14 Synthesis and Antibacterial Activity of Oxygenated Boronic Acid Substituted a-Cyanostilbenes

Presenter Information

Yewon Kim, Andrews UniversityFollow

Start Date

3-2-2018 2:30 PM

Description

Stilbenes are naturally occurring compounds that have exhibited antibacterial activity, although the biological effect of various stilbenes is different for Gram-positive and Gram-negative strains of bacteria. In prior research, cyanostilbenes have shown “slight” antibacterial activity (Brownlee, et al. 1943). This project aims to explore whether hybrid oxygenated a-cyanostilbenes possessing a boronic acid pharmacophore exhibits significant antibacterial activity (Das, et al., 2013). The biological activity against both Gram-positive and Gram-negative strains will be tested.

Acknowledgments

Dr. Desmond Murray.

J. N. Andrews Honors Program.

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Mar 2nd, 2:30 PM

P-14 Synthesis and Antibacterial Activity of Oxygenated Boronic Acid Substituted a-Cyanostilbenes

Stilbenes are naturally occurring compounds that have exhibited antibacterial activity, although the biological effect of various stilbenes is different for Gram-positive and Gram-negative strains of bacteria. In prior research, cyanostilbenes have shown “slight” antibacterial activity (Brownlee, et al. 1943). This project aims to explore whether hybrid oxygenated a-cyanostilbenes possessing a boronic acid pharmacophore exhibits significant antibacterial activity (Das, et al., 2013). The biological activity against both Gram-positive and Gram-negative strains will be tested.