P-14 Synthesis and Antibacterial Activity of Oxygenated Boronic Acid Substituted a-Cyanostilbenes
Abstract
Stilbenes are naturally occurring compounds that have exhibited antibacterial activity, although the biological effect of various stilbenes is different for Gram-positive and Gram-negative strains of bacteria. In prior research, cyanostilbenes have shown “slight” antibacterial activity (Brownlee, et al. 1943). This project aims to explore whether hybrid oxygenated a-cyanostilbenes possessing a boronic acid pharmacophore exhibits significant antibacterial activity (Das, et al., 2013). The biological activity against both Gram-positive and Gram-negative strains will be tested.
Start Date
3-2-2018 2:30 PM
P-14 Synthesis and Antibacterial Activity of Oxygenated Boronic Acid Substituted a-Cyanostilbenes
Stilbenes are naturally occurring compounds that have exhibited antibacterial activity, although the biological effect of various stilbenes is different for Gram-positive and Gram-negative strains of bacteria. In prior research, cyanostilbenes have shown “slight” antibacterial activity (Brownlee, et al. 1943). This project aims to explore whether hybrid oxygenated a-cyanostilbenes possessing a boronic acid pharmacophore exhibits significant antibacterial activity (Das, et al., 2013). The biological activity against both Gram-positive and Gram-negative strains will be tested.
Acknowledgments
Dr. Desmond Murray.
J. N. Andrews Honors Program.