Event Title

P-10 The Colored Dendrimer Synthesis Project

Presenter Information

Jesse Gray, Andrews UniversityFollow

Start Date

3-2-2018 2:30 PM

Description

PAMAM dendrimers are nanosized spherical, highly-branched polymers that are being developed for drug solubilization, targeted drug delivery, DNA/siRNA transfection, MRI contrast agents, and tracking biochemical processes. Commercially available dendrimers are colorless and require additional synthesis to attach chromophores. The research demonstrates how to build a PAMAM dendrimer around colored core molecule. Perylenetetracarboxylic dianhydride is a stable, red, fluorescent chromophore that was transformed into a diamine then into the traditional PAMAM structure using methyl acrylate followed by ethylenediamine. The resulting G0 dendrimer is studied by NMR and mass spectroscopy along with optical spectroscopy to characterize this new red PAMAM dendrimer.

Acknowledgments

Dr. Ryan T. Hayes.

J. N. Andrews Honors Program.

AU Office of Research & Creative Scholarship.

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Mar 2nd, 2:30 PM

P-10 The Colored Dendrimer Synthesis Project

PAMAM dendrimers are nanosized spherical, highly-branched polymers that are being developed for drug solubilization, targeted drug delivery, DNA/siRNA transfection, MRI contrast agents, and tracking biochemical processes. Commercially available dendrimers are colorless and require additional synthesis to attach chromophores. The research demonstrates how to build a PAMAM dendrimer around colored core molecule. Perylenetetracarboxylic dianhydride is a stable, red, fluorescent chromophore that was transformed into a diamine then into the traditional PAMAM structure using methyl acrylate followed by ethylenediamine. The resulting G0 dendrimer is studied by NMR and mass spectroscopy along with optical spectroscopy to characterize this new red PAMAM dendrimer.