Poster Title
P-10 The Colored Dendrimer Synthesis Project
Abstract
PAMAM dendrimers are nanosized spherical, highly-branched polymers that are being developed for drug solubilization, targeted drug delivery, DNA/siRNA transfection, MRI contrast agents, and tracking biochemical processes. Commercially available dendrimers are colorless and require additional synthesis to attach chromophores. The research demonstrates how to build a PAMAM dendrimer around colored core molecule. Perylenetetracarboxylic dianhydride is a stable, red, fluorescent chromophore that was transformed into a diamine then into the traditional PAMAM structure using methyl acrylate followed by ethylenediamine. The resulting G0 dendrimer is studied by NMR and mass spectroscopy along with optical spectroscopy to characterize this new red PAMAM dendrimer.
Start Date
3-2-2018 2:30 PM
P-10 The Colored Dendrimer Synthesis Project
PAMAM dendrimers are nanosized spherical, highly-branched polymers that are being developed for drug solubilization, targeted drug delivery, DNA/siRNA transfection, MRI contrast agents, and tracking biochemical processes. Commercially available dendrimers are colorless and require additional synthesis to attach chromophores. The research demonstrates how to build a PAMAM dendrimer around colored core molecule. Perylenetetracarboxylic dianhydride is a stable, red, fluorescent chromophore that was transformed into a diamine then into the traditional PAMAM structure using methyl acrylate followed by ethylenediamine. The resulting G0 dendrimer is studied by NMR and mass spectroscopy along with optical spectroscopy to characterize this new red PAMAM dendrimer.
Acknowledgments
Dr. Ryan T. Hayes.
J. N. Andrews Honors Program.
AU Office of Research & Creative Scholarship.