P-25 Screening of Ylidene Rhodanines as Effective Metal Detectors

Buller Hall

In this phase of our project we are conducting broad screens of previously synthesized ylidene rhodanines to explore their metal sensing capabilities. This communication will discuss our results to date. Our long-term goal is development of liquid crystalline ylidene rhodanines for novel applications in histochemistry. Based on ongoing work in Prof Murray’s lab, with undergraduates and high school students, a new ‘green’ approach has been developed for facile synthesis of ylidene rhodanines. This prior synthesis facilitates exploring new applications for arylidene rhodanines in areas of biomedical and material science. Imaging of metals in human tissue is an important area of biomedical research and technology since metal (especially zinc, iron, and copper) imbalance is increasingly found to be critical in a number of diseases, such as, Alzheimer’s, Parkinson’s and Wilson’s.