Poster Title
Abstract
Heterocyclic Amines (HCAs) are a group of mutagenic and carcinogenic chemicals found in muscle meat after grilling, frying, or broiling. Research studies show that very low amounts of HCAs are created from creatinine reacting with another amino acid at temperatures greater than 200 °C. Other studies show that plant-based arginine can substitute for creatine forming a new class of mutagenic HCAs, but also in low yields. We sought to develop a direct, higher yielding method of producing these arginine-HCAs based on a procedure previously used to synthesize creatine-HCAs. Greater amounts of arginine-HCA speeds analysis, chemical characterization, and toxicity assessment.
Thesis Record URL
Location
Buller Hallway
Start Date
3-6-2015 2:30 PM
End Date
3-6-2015 4:00 PM
P-24 Synthesis of Arginine-Based Heterocyclic Amines
Buller Hallway
Heterocyclic Amines (HCAs) are a group of mutagenic and carcinogenic chemicals found in muscle meat after grilling, frying, or broiling. Research studies show that very low amounts of HCAs are created from creatinine reacting with another amino acid at temperatures greater than 200 °C. Other studies show that plant-based arginine can substitute for creatine forming a new class of mutagenic HCAs, but also in low yields. We sought to develop a direct, higher yielding method of producing these arginine-HCAs based on a procedure previously used to synthesize creatine-HCAs. Greater amounts of arginine-HCA speeds analysis, chemical characterization, and toxicity assessment.
Acknowledgments
J.N. Andrews Honors Scholar and Undergraduate Research Scholar
Advisor: Ryan Hayes, Chemistry & Biochemistry