Date of Award

4-5-2020

Document Type

Honors Thesis

Department

Chemistry & Biochemistry

First Advisor

Desmond Murray

Abstract

Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that originates from glial cells, which make up the supportive tissue surrounding neurons. Temozolomide (TMZ) is the current chemotherapeutic drug administered to treat GBM as it works to inhibit the growth of the cancer cells. This research study focused on developing a method for synthesizing novel hybrid compounds that combines TMZ with various fatty acids known to have anticancer properties, forming a series of imide compounds with potential chemotherapeutic effects. Before synthesizing the compounds, various methods for synthesizing an imide from a primary amide were tested to ensure that TMZ and fatty acids would successfully react with each other to form the novel hybrid compounds. Once the novel hybrid compounds are synthesized, they will be tested for their anticancer properties on glioblastoma cells.

Subject Area

Glioblastoma multiforme; Imides

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