Date of Award

4-26-2020

Document Type

Honors Thesis

Department

Biology

First Advisor

Denise Smith

Abstract

The purpose of this research is to develop a new technique to synthesize a heterocyclic arylidene compound using fruit puree catalysis and investigate its anti-cancer activity on glioblastoma cancer cells. Recently, there has been interest in heterocycles due to their anticancer properties and they have been used in almost two-thirds of the novel molecular anticancer agents. Varying fruit purees were used to synthesize a novel hybrid arylidene pyrazolone from 3-methyl-1-phenyl-5-pyrazolone and 4-dimethylaminobenzaldehyde by modifying methodology developed by Dr. Murray. This arylidene pyrazolone was then tested for its anticancer activity on glioblastoma brain cancer cells using Dr. Smith’s 12-well cell viability assay. The reagent and arylidene pyrazolone from two experiments that was tested for cell viability had notable anti-cellular effects of varying potencies. In future studies, (a) more fruits could be tested for their effectiveness in synthesis, (b) more arylidene pyrazolones can be synthesized, and (c) both the fruit puree and the purified products can be tested to determine their efficacy in inhibiting the initiation of tumors and for their anti-invasive properties.

Subject Area

Pyrazolones; Glioblastoma multiforme; Antineoplastic agents

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Included in

Biology Commons

Share

COinS