Date of Award

4-22-2020

Document Type

Honors Thesis

Department

Biology

First Advisor

Denise Smith

Abstract

Glioblastoma multiforme, is a type of brain cancer that develops from glial cells, which surround neurons and provide support and insulation. Previous investigation has shown that some heterocyclic compounds are key in improving the properties of anticancer drugs by enhancing lipophilicity, polarity, and other varying physiochemical features. Synthetic heterocyclic compounds used as anticancer drugs attempt to imitate naturally-occurring ligands and substrates so as to disturb the natural balance in cells. Testing was done to determine the anticancer abilities of hybrid compounds, heterocyclic arylidenes, containing various functional groups, including boronic acids, through a three-day testing process. These compounds were previous synthesized by Jemma McLeish. This was done in order to determine whether the compounds have no effect on glioblastoma viability, increased viability of glioblastoma, or decreased viability of glioblastoma. Results show that only one compound, rhodanine + p-tolualdehyde, was successful, while the other three compounds, rhodanine + o-tolualdehyde, rhodanine + 2-fluoro-4-formylphenylboronic acid, and rhodanine + 3-fluoro-4-formylphenylboronic acid, caused growth acceleration.

Subject Area

Heterocyclic compounds; Glioblastoma multiforme; Antineoplastic agents

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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