Date of Award
4-22-2020
Document Type
Honors Thesis
Department
Biology
First Advisor
Denise Smith
Abstract
Glioblastoma multiforme, is a type of brain cancer that develops from glial cells, which surround neurons and provide support and insulation. Previous investigation has shown that some heterocyclic compounds are key in improving the properties of anticancer drugs by enhancing lipophilicity, polarity, and other varying physiochemical features. Synthetic heterocyclic compounds used as anticancer drugs attempt to imitate naturally-occurring ligands and substrates so as to disturb the natural balance in cells. Testing was done to determine the anticancer abilities of hybrid compounds, heterocyclic arylidenes, containing various functional groups, including boronic acids, through a three-day testing process. These compounds were previous synthesized by Jemma McLeish. This was done in order to determine whether the compounds have no effect on glioblastoma viability, increased viability of glioblastoma, or decreased viability of glioblastoma. Results show that only one compound, rhodanine + p-tolualdehyde, was successful, while the other three compounds, rhodanine + o-tolualdehyde, rhodanine + 2-fluoro-4-formylphenylboronic acid, and rhodanine + 3-fluoro-4-formylphenylboronic acid, caused growth acceleration.
Recommended Citation
Flores, Bernadette, "Evaluation of Anticancer Activity of Heterocyclic Arylidenes on the U87MG cancer cell line" (2020). Honors Theses. 228.
https://dx.doi.org/10.32597/honors/228/
https://digitalcommons.andrews.edu/honors/228
Subject Area
Heterocyclic compounds; Glioblastoma multiforme; Antineoplastic agents
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/228/