Date of Award

4-6-2019

Document Type

Honors Thesis

Department

Chemistry & Biochemistry

First Advisor

Lisa Ahlberg

Abstract

Progression of Alzheimer's disease is associated with a loss of Ml receptor activation in the brain. However, a lack of clinical success following attempts to activate the Ml receptor at the orthosteric site has contributed to a transition towards the allosteric pocket of the receptor. Here, positive allosteric modulators (PAMs) interact to potentiate the acetylcholine response. Recent research proposes that optimization of PAM activity at the expense of intrinsic agonism may posit a means to limit adverse side effects. Therefore, this project proposes a design and synthesis of a novel isoxazoline as a potent PAM agent with weak intrinsic agonism.

Subject Area

Allosteric regulation; Alzeheimer's disease, Isoxazoline

Creative Commons License

Creative Commons Attribution-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 License.

DOI

https://dx.doi.org/10.32597/honors/215

Files over 3MB may be slow to open. For best results, right-click and select "save as..."

Share

COinS