Date of Award
2011
Document Type
Honors Thesis
Department
Biology
First Advisor
Marlene Murray-Nseula
Second Advisor
Desmond Murray
Abstract
Bipolar disorder is a psychiatric disorder characterized by episodes of abnormally elevated mood followed by periods of extreme depression. Currently, valproate is one of the drugs used to treat the disorder but it is associated with many negative side effects. The goal of this project is to create a prodrug with structural similarities to valproate and determine if its effect on growth of the yeast Saccharomyces cerevisiae is similar to that of valproate. Yeast cells were grown in media with or without the prodrug in the presence or absence of inositol. The results showed that the prodrug inhibited growth.
Recommended Citation
Thompson, Lisa, "The Effects of Valproate Prodrugs on the Inositol Biosynthetic Pathway in Saccharomyces Cerevisiae Yeast" (2011). Honors Theses. 21.
https://dx.doi.org/10.32597/honors/21/
https://digitalcommons.andrews.edu/honors/21
Subject Area
Valproic acid., Saccharomyces cerevisiae, Inositol
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/21/