Date of Award

4-3-2019

Document Type

Honors Thesis

Department

Chemistry & Biochemistry

First Advisor

Lisa Ahlberg

Abstract

Due to the growing need of antibiotics in modern day medicine, this study attempts to apply a method of medicinal chemistry that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecules would create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the zinc ion. Recent developments have demonstrated that the inhibitor proposed may have had high inhibitory potential. Further, current research suggests that the current inhibitor proposed may also be ineffective against a specific method of bacterial resistance towards antibiotics.

Subject Area

Chemical inhibitors; Enzymes; Antibiotics

DOI

https://dx.doi.org/10.32597/honors/206

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