Poster Title
P-25 Synthesis of Isoxazoline Derivatives as Potential Anti-Cancer Agents
Abstract
Isoxazolines are organic molecules known for their diverse functionality in medicinal chemistry, including their anti-cancer activity. In a study on dibenzoazepine tethered isoxazoline (DBI) derivatives as possible anti-cancer agents, combining the potential DNA-damaging effects of dibenzoazepines and isoxazolines, results showed increased inhibition of invasion, migration and proliferation of some cancer cells. PK11195, a benzodiazepine derivative, also has known anti-cancer activity through alternative mechanisms still actively studied. My research aims to design and synthesize an organic molecule exhibiting key structural qualities of both DBI and PK11195, hopefully combining the individual functionalities of both, to form a molecule with greater anti-cancer activity.
Location
Buller Hallway
Start Date
3-6-2015 2:30 PM
End Date
3-6-2015 4:00 PM
P-25 Synthesis of Isoxazoline Derivatives as Potential Anti-Cancer Agents
Buller Hallway
Isoxazolines are organic molecules known for their diverse functionality in medicinal chemistry, including their anti-cancer activity. In a study on dibenzoazepine tethered isoxazoline (DBI) derivatives as possible anti-cancer agents, combining the potential DNA-damaging effects of dibenzoazepines and isoxazolines, results showed increased inhibition of invasion, migration and proliferation of some cancer cells. PK11195, a benzodiazepine derivative, also has known anti-cancer activity through alternative mechanisms still actively studied. My research aims to design and synthesize an organic molecule exhibiting key structural qualities of both DBI and PK11195, hopefully combining the individual functionalities of both, to form a molecule with greater anti-cancer activity.
Acknowledgments
J.N. Andrews Honors Scholar and Undergraduate Research Scholar
Advisor: Lisa Ahlberg, Chemistry & Biochemistry