Event Title

P-31 Synthesis of Isoxazoline as a PAM Activator

Location

Buller Hall 150

Start Date

3-11-2022 1:30 PM

End Date

3-11-2022 3:30 PM

Department

Chemistry and Biochemistry

Description

Alzheimer’s disease (AD) is correlated to degeneration of muscarinic acetylcholine receptors (mAChR). Activation of M1 receptor (G protein) with positive allosteric modulator (PAM) has shown to bind to the receptor slowing the degeneration. Structural motifs with PAMs, that provides potent activity and weak agonism indicates a novel isoxazoline compound containing a top, core, and pendant motif. Our strategy was to synthesize the isoxazoline pendant first, followed by the core and top motif attachment. We observed that the reactions to form the pendant motif have not yet provided a substantive yield and further experimentation is required.

Acknowledgments

Advisor: Lisa Ahlberg, Chemistry & Biochemistry

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Mar 11th, 1:30 PM Mar 11th, 3:30 PM

P-31 Synthesis of Isoxazoline as a PAM Activator

Buller Hall 150

Alzheimer’s disease (AD) is correlated to degeneration of muscarinic acetylcholine receptors (mAChR). Activation of M1 receptor (G protein) with positive allosteric modulator (PAM) has shown to bind to the receptor slowing the degeneration. Structural motifs with PAMs, that provides potent activity and weak agonism indicates a novel isoxazoline compound containing a top, core, and pendant motif. Our strategy was to synthesize the isoxazoline pendant first, followed by the core and top motif attachment. We observed that the reactions to form the pendant motif have not yet provided a substantive yield and further experimentation is required.