Poster Title
P-31 Synthesis of Isoxazoline as a PAM Activator
Department
Chemistry and Biochemistry
Abstract
Alzheimer’s disease (AD) is correlated to degeneration of muscarinic acetylcholine receptors (mAChR). Activation of M1 receptor (G protein) with positive allosteric modulator (PAM) has shown to bind to the receptor slowing the degeneration. Structural motifs with PAMs, that provides potent activity and weak agonism indicates a novel isoxazoline compound containing a top, core, and pendant motif. Our strategy was to synthesize the isoxazoline pendant first, followed by the core and top motif attachment. We observed that the reactions to form the pendant motif have not yet provided a substantive yield and further experimentation is required.
Location
Buller Hall 150
Start Date
3-11-2022 1:30 PM
End Date
3-11-2022 3:30 PM
P-31 Synthesis of Isoxazoline as a PAM Activator
Buller Hall 150
Alzheimer’s disease (AD) is correlated to degeneration of muscarinic acetylcholine receptors (mAChR). Activation of M1 receptor (G protein) with positive allosteric modulator (PAM) has shown to bind to the receptor slowing the degeneration. Structural motifs with PAMs, that provides potent activity and weak agonism indicates a novel isoxazoline compound containing a top, core, and pendant motif. Our strategy was to synthesize the isoxazoline pendant first, followed by the core and top motif attachment. We observed that the reactions to form the pendant motif have not yet provided a substantive yield and further experimentation is required.
Acknowledgments
Advisor: Lisa Ahlberg, Chemistry & Biochemistry