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Session

Department of Chemistry & Biochemistry

Event Website

https://www.andrews.edu/services/research/research_events/conferences/urs_honors_poster_symposium/index.html

Start Date

3-26-2021 2:40 PM

End Date

3-26-2021 3:00 PM

Department

Chemistry and Biochemistry

Description

Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that originates from glial cells, which make up the supportive tissue surrounding neurons. Temozolomide (TMZ) is the current chemotherapeutic drug administered to treat GBM as it works to inhibit the growth of the cancer cells. This research study focuses on developing a method for synthesizing novel hybrid compounds that combines TMZ with various fatty acids known to have anticancer properties, forming a series of imide compounds with potential chemotherapeutic effects. Once the novel hybrid compounds are successfully synthesized, they will be tested for their anticancer properties on glioblastoma cells.

Acknowledgments

Advisor: Desmond Murray

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Mar 26th, 2:40 PM Mar 26th, 3:00 PM

Synthesis of Novel Temozolomide-Fatty Acid Imide Hybrid Compounds for the Chemotherapeutic Treatment of Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that originates from glial cells, which make up the supportive tissue surrounding neurons. Temozolomide (TMZ) is the current chemotherapeutic drug administered to treat GBM as it works to inhibit the growth of the cancer cells. This research study focuses on developing a method for synthesizing novel hybrid compounds that combines TMZ with various fatty acids known to have anticancer properties, forming a series of imide compounds with potential chemotherapeutic effects. Once the novel hybrid compounds are successfully synthesized, they will be tested for their anticancer properties on glioblastoma cells.

https://digitalcommons.andrews.edu/honors-undergraduate-poster-symposium/2021/symposium/15