Event Title

P-07 Evaluation of Anticancer Activity of Heterocyclic Arylidenes on the U87MG (Brain) Cancer Cell Line

Presenter Information

Bernadette Flores

Start Date

2-28-2020 2:30 PM

Description

Glioblastoma multiforme is a type of brain cancer that develops from glial cells, which surround neurons and provide support and insulation. Previous investigation has shown that some heterocyclic compounds are key in improving the properties of anticancer drugs by enhancing lipophilicity, polarity, and other varying physiochemical features. Synthetic heterocyclic compounds used as anticancer drugs attempt to imitate naturally-occurring ligands and substrates so as to disturb the natural balance in cells. Testing was done to determine the anticancer abilities of boronic acid and non-boronic acid substituents at various positions on the aromatic ring of the compounds using a cell viability count.

Acknowledgments

J.N. Andrews Honors Scholar

Mentor:

Denise Smith, Biology

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Feb 28th, 2:30 PM

P-07 Evaluation of Anticancer Activity of Heterocyclic Arylidenes on the U87MG (Brain) Cancer Cell Line

Glioblastoma multiforme is a type of brain cancer that develops from glial cells, which surround neurons and provide support and insulation. Previous investigation has shown that some heterocyclic compounds are key in improving the properties of anticancer drugs by enhancing lipophilicity, polarity, and other varying physiochemical features. Synthetic heterocyclic compounds used as anticancer drugs attempt to imitate naturally-occurring ligands and substrates so as to disturb the natural balance in cells. Testing was done to determine the anticancer abilities of boronic acid and non-boronic acid substituents at various positions on the aromatic ring of the compounds using a cell viability count.