Poster Title
P-06 Synthesis of Pyrazolones and the Novel Hybrid’s Effects on Glioblastoma Cancer Cells
Abstract
The purpose of this research is to develop a new technique to synthesize a heterocyclic compound using fruit puree, investigating its anti-cancer activity on glioblastoma cancer cells. Recently, there has been interest in heterocycles due to their anti-cancer properties, and they have been used in almost two-thirds of novel molecular anti-cancer agents. Varying fruit purees have been used to synthesize the compound 3-methyl-1-phenyl-5-pyrazolone and tested for their anti-cancer activity on glioblastoma brain cancer cells. The compounds tested for cell viability had notable anti-cellular effects of varying potencies. In future studies, more fruits could be tested for their effectiveness in synthesis and tested to determine the novel hybrid’s efficacy in inhibiting the initiation of tumors as well as its anti-invasive properties.
Start Date
2-28-2020 2:30 PM
P-06 Synthesis of Pyrazolones and the Novel Hybrid’s Effects on Glioblastoma Cancer Cells
The purpose of this research is to develop a new technique to synthesize a heterocyclic compound using fruit puree, investigating its anti-cancer activity on glioblastoma cancer cells. Recently, there has been interest in heterocycles due to their anti-cancer properties, and they have been used in almost two-thirds of novel molecular anti-cancer agents. Varying fruit purees have been used to synthesize the compound 3-methyl-1-phenyl-5-pyrazolone and tested for their anti-cancer activity on glioblastoma brain cancer cells. The compounds tested for cell viability had notable anti-cellular effects of varying potencies. In future studies, more fruits could be tested for their effectiveness in synthesis and tested to determine the novel hybrid’s efficacy in inhibiting the initiation of tumors as well as its anti-invasive properties.
Acknowledgments
J.N. Andrews Honors Scholar
Mentors:
Denise Smith, Biology
Desmond H. Murray, Chemistry & Biochemistry