Event Title

P-06 Synthesis of Pyrazolones and the Novel Hybrid’s Effects on Glioblastoma Cancer Cells

Presenter Information

Joanna Deonarine

Start Date

2-28-2020 2:30 PM

Description

The purpose of this research is to develop a new technique to synthesize a heterocyclic compound using fruit puree, investigating its anti-cancer activity on glioblastoma cancer cells. Recently, there has been interest in heterocycles due to their anti-cancer properties, and they have been used in almost two-thirds of novel molecular anti-cancer agents. Varying fruit purees have been used to synthesize the compound 3-methyl-1-phenyl-5-pyrazolone and tested for their anti-cancer activity on glioblastoma brain cancer cells. The compounds tested for cell viability had notable anti-cellular effects of varying potencies. In future studies, more fruits could be tested for their effectiveness in synthesis and tested to determine the novel hybrid’s efficacy in inhibiting the initiation of tumors as well as its anti-invasive properties.

Acknowledgments

J.N. Andrews Honors Scholar

Mentors:

Denise Smith, Biology

Desmond H. Murray, Chemistry & Biochemistry

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Feb 28th, 2:30 PM

P-06 Synthesis of Pyrazolones and the Novel Hybrid’s Effects on Glioblastoma Cancer Cells

The purpose of this research is to develop a new technique to synthesize a heterocyclic compound using fruit puree, investigating its anti-cancer activity on glioblastoma cancer cells. Recently, there has been interest in heterocycles due to their anti-cancer properties, and they have been used in almost two-thirds of novel molecular anti-cancer agents. Varying fruit purees have been used to synthesize the compound 3-methyl-1-phenyl-5-pyrazolone and tested for their anti-cancer activity on glioblastoma brain cancer cells. The compounds tested for cell viability had notable anti-cellular effects of varying potencies. In future studies, more fruits could be tested for their effectiveness in synthesis and tested to determine the novel hybrid’s efficacy in inhibiting the initiation of tumors as well as its anti-invasive properties.