P-43 Improving the Discovery of Mutagenic Arginine-based Heterocyclic Amines

Buller Hall Lobby

Previous research has demonstrated that creatinine and other amino acids in meat, when cooked at high temperatures, produces a class of carcinogenic molecules called heterocyclic amines (HCA). Our research suggests that mutagenic HCAs may be created by substituting arginine for creatinine. Burned arginine-threonine mixtures have been the focus of the current research. They have been used to determine methods that reproducibly produce mutagenic compounds indicated by the Ames test. Studies into the methods of burning, extraction, and purification aim to improve the production and recovery of mutagenic compounds. These details will be presented on various arginine-threonine burnings.