Event Title

P-04 Effect of Novel Thiohydantoin-Aldehyde Compounds on Glioblastoma Cell Viability

Location

Buller Hall Lobby

Start Date

3-8-2019 2:30 PM

Description

Hydantoin derivatives and heterocyclic aldehydes may be effective in diminishing the viability of glioblastoma cells. The goal of this project is to synthesize novel thiohydantoin-aldehyde hybrid compounds and determine the effect of those compounds on glioblastoma cell viability. Compounds are synthesized using a catalyst in a reflux procedure followed by purification via extraction. Testing is performed via a three-day LD50 assay. Varying concentrations of a compound is added to a 12-well plate containing glioblastoma cells. The viability of the treated cells is then analyzed using a crystal violet stain. Several compounds have been synthesized and testing is ongoing.

Acknowledgments

Supervising Professors: Dr. Denise Smith (primary advisor) & Dr. Desmond Murray (secondary advisor)

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Mar 8th, 2:30 PM

P-04 Effect of Novel Thiohydantoin-Aldehyde Compounds on Glioblastoma Cell Viability

Buller Hall Lobby

Hydantoin derivatives and heterocyclic aldehydes may be effective in diminishing the viability of glioblastoma cells. The goal of this project is to synthesize novel thiohydantoin-aldehyde hybrid compounds and determine the effect of those compounds on glioblastoma cell viability. Compounds are synthesized using a catalyst in a reflux procedure followed by purification via extraction. Testing is performed via a three-day LD50 assay. Varying concentrations of a compound is added to a 12-well plate containing glioblastoma cells. The viability of the treated cells is then analyzed using a crystal violet stain. Several compounds have been synthesized and testing is ongoing.