Event Title

P-13 Methodology for the Synthesis of an Antibacterial Isoxazoline Ring

Presenter Information

Taejun Lee, Andrews University

Location

Buller Hall Lobby

Start Date

3-8-2019 2:30 PM

Description

Due to the growing need of antibiotics in modern day medicine, this study attempts to find a method that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecule to create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the active site zinc ion.

Acknowledgments

Supervising Professor: Dr. Lisa Ahlberg

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Mar 8th, 2:30 PM

P-13 Methodology for the Synthesis of an Antibacterial Isoxazoline Ring

Buller Hall Lobby

Due to the growing need of antibiotics in modern day medicine, this study attempts to find a method that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecule to create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the active site zinc ion.