Event Title

P-51 Synthesis and Activity of Novel Dual Binding Transfectors

Start Date

3-2-2018 2:30 PM

Description

The purpose of this interdisciplinary chemistry-biology project involves the synthesis and transfecting capabilities of arylidene thiobarbituric alkylpyridinium (ATAP) salts. Our research involves designing, synthesizing and testing novel dual binding transfectors capable of both electrostatic attractions and hydrogen-bonding as the means of nucleic acid complexation and ultimately transfection. To our knowledge, this sort of dual-binding transfector has not been made before, and we anticipate that it could offer some advantages over the currently available commercial transfecting agents. Transfectors are essential "tools" for cutting-edge biomedical technologies such as gene editing, gene therapy and cloning.

Acknowledgments

Desmond Hartwell Murray, PhD.

Office of Research & Creative Scholarship.

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Mar 2nd, 2:30 PM

P-51 Synthesis and Activity of Novel Dual Binding Transfectors

The purpose of this interdisciplinary chemistry-biology project involves the synthesis and transfecting capabilities of arylidene thiobarbituric alkylpyridinium (ATAP) salts. Our research involves designing, synthesizing and testing novel dual binding transfectors capable of both electrostatic attractions and hydrogen-bonding as the means of nucleic acid complexation and ultimately transfection. To our knowledge, this sort of dual-binding transfector has not been made before, and we anticipate that it could offer some advantages over the currently available commercial transfecting agents. Transfectors are essential "tools" for cutting-edge biomedical technologies such as gene editing, gene therapy and cloning.