Poster Title
P-20 Effect of Omega-3-DHA on Myo-inositol Level and Gene Expression of INO1
Abstract
Bipolar disorder is a mental disorder characterized by repeated episodes of mania and depression. Its current treatment often entails inefficacy and side effects. Omega-3-fatty acids have been found to improve bipolar disorder symptoms without significant aftereffects, and it is hypothetically attributed for its ability to alter the level of myo-inositol. Thus, the goal of this study is to determine the effects of the omega-3-decosahexaenoic acid (DHA) on intracellular myo-inositol levels and the expression of the myo-inositol synthase gene, INO1. Extracts of cells grown in the presence of DHA were assayed for myo-inositol results support the hypothesis that DHA can ameliorate bipolar disorder by increasing myo-inositol levels, which probably leads to a decrease in myo-inositol INO1.
Thesis Record URL
https://digitalcommons.andrews.edu/honors/191
Start Date
3-2-2018 2:30 PM
P-20 Effect of Omega-3-DHA on Myo-inositol Level and Gene Expression of INO1
Bipolar disorder is a mental disorder characterized by repeated episodes of mania and depression. Its current treatment often entails inefficacy and side effects. Omega-3-fatty acids have been found to improve bipolar disorder symptoms without significant aftereffects, and it is hypothetically attributed for its ability to alter the level of myo-inositol. Thus, the goal of this study is to determine the effects of the omega-3-decosahexaenoic acid (DHA) on intracellular myo-inositol levels and the expression of the myo-inositol synthase gene, INO1. Extracts of cells grown in the presence of DHA were assayed for myo-inositol results support the hypothesis that DHA can ameliorate bipolar disorder by increasing myo-inositol levels, which probably leads to a decrease in myo-inositol INO1.
Acknowledgments
Dr. Marlene Murray.
AU Office of Research & Creative Scholarship.