Event Title

P-20 Effect of Omega-3-DHA on Myo-inositol Level and Gene Expression of INO1

Presenter Information

Taejun Ok, Andrews UniversityFollow

Start Date

3-2-2018 2:30 PM

Description

Bipolar disorder is a mental disorder characterized by repeated episodes of mania and depression. Its current treatment often entails inefficacy and side effects. Omega-3-fatty acids have been found to improve bipolar disorder symptoms without significant aftereffects, and it is hypothetically attributed for its ability to alter the level of myo-inositol. Thus, the goal of this study is to determine the effects of the omega-3-decosahexaenoic acid (DHA) on intracellular myo-inositol levels and the expression of the myo-inositol synthase gene, INO1. Extracts of cells grown in the presence of DHA were assayed for myo-inositol results support the hypothesis that DHA can ameliorate bipolar disorder by increasing myo-inositol levels, which probably leads to a decrease in myo-inositol INO1.

Acknowledgments

Dr. Marlene Murray.

AU Office of Research & Creative Scholarship.

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Mar 2nd, 2:30 PM

P-20 Effect of Omega-3-DHA on Myo-inositol Level and Gene Expression of INO1

Bipolar disorder is a mental disorder characterized by repeated episodes of mania and depression. Its current treatment often entails inefficacy and side effects. Omega-3-fatty acids have been found to improve bipolar disorder symptoms without significant aftereffects, and it is hypothetically attributed for its ability to alter the level of myo-inositol. Thus, the goal of this study is to determine the effects of the omega-3-decosahexaenoic acid (DHA) on intracellular myo-inositol levels and the expression of the myo-inositol synthase gene, INO1. Extracts of cells grown in the presence of DHA were assayed for myo-inositol results support the hypothesis that DHA can ameliorate bipolar disorder by increasing myo-inositol levels, which probably leads to a decrease in myo-inositol INO1.