Event Title

Development of a Synthetic Method for Acyl Ureas from Aspirin

Presenter Information

Jessica Yoong, Andrews University

Location

Buller Hall

Start Date

3-3-2017 2:30 PM

End Date

3-3-2017 4:00 PM

Description

The objective of this project is to develop a synthetic method for acyl ureas from aspirin and analyze the effects of various amines on the aspirin acyl urea synthesis. Acyl ureas are known to have important biological effects, such as being insecticides, antidiabetics, anticonvulsants, and sedatives. This project investigates the possible ‘hybrid’ properties of acyl ureas made from aspirin to determine whether they show unique biological activities. Our ‘one-pot’ synthetic procedure converts aspirin into its acid chloride, then an acyl isocyanate, and finally to an acyl urea using different amines. We tested fifteen different amines using our optimized reaction conditions.

Acknowledgments

Dr. Desmond H. Murray

This document is currently not available here.

Share

COinS
 
Mar 3rd, 2:30 PM Mar 3rd, 4:00 PM

Development of a Synthetic Method for Acyl Ureas from Aspirin

Buller Hall

The objective of this project is to develop a synthetic method for acyl ureas from aspirin and analyze the effects of various amines on the aspirin acyl urea synthesis. Acyl ureas are known to have important biological effects, such as being insecticides, antidiabetics, anticonvulsants, and sedatives. This project investigates the possible ‘hybrid’ properties of acyl ureas made from aspirin to determine whether they show unique biological activities. Our ‘one-pot’ synthetic procedure converts aspirin into its acid chloride, then an acyl isocyanate, and finally to an acyl urea using different amines. We tested fifteen different amines using our optimized reaction conditions.